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NPN Certified (80129303)
Pharmacist Formulated
100% Plant-Based
Non-GMO
Dairy-Free
Gluten-Free
Soy-Free
Made in USA
6 Clinically Studied Strains
Non-Sedating
Caffeine-Free
NPN Certified (80129303)
Pharmacist Formulated
100% Plant-Based
Non-GMO
Dairy-Free
Gluten-Free
Soy-Free
Made in USA
6 Clinically Studied Strains
Non-Sedating
Caffeine-Free
NPN Certified (80129303)
Pharmacist Formulated
100% Plant-Based
Non-GMO
Dairy-Free
Gluten-Free
Soy-Free
Made in USA
6 Clinically Studied Strains
Non-Sedating
Caffeine-Free
NPN Certified (80129303)
Pharmacist Formulated
100% Plant-Based
Non-GMO
Dairy-Free
Gluten-Free
Soy-Free
Made in USA
6 Clinically Studied Strains
Non-Sedating
Caffeine-Free
NPN Certified (80129303)
Pharmacist Formulated
100% Plant-Based
Non-GMO
Dairy-Free
Gluten-Free
Soy-Free
Made in USA
6 Clinically Studied Strains
Non-Sedating
Caffeine-Free
NPN Certified (80129303)
Pharmacist Formulated
100% Plant-Based
Non-GMO
Dairy-Free
Gluten-Free
Soy-Free
Made in USA
6 Clinically Studied Strains
Non-Sedating
Caffeine-Free
NPN Certified (80129303)
Pharmacist Formulated
100% Plant-Based
Non-GMO
Dairy-Free
Gluten-Free
Soy-Free
Made in USA
6 Clinically Studied Strains
Non-Sedating
Caffeine-Free
NPN Certified (80129303)
Pharmacist Formulated
100% Plant-Based
Non-GMO
Dairy-Free
Gluten-Free
Soy-Free
Made in USA
6 Clinically Studied Strains
Non-Sedating
Caffeine-Free
NPN Certified (80129303)
Pharmacist Formulated
100% Plant-Based
Non-GMO
Dairy-Free
Gluten-Free
Soy-Free
Made in USA
6 Clinically Studied Strains
Non-Sedating
Caffeine-Free
NPN Certified (80129303)
Pharmacist Formulated
100% Plant-Based
Non-GMO
Dairy-Free
Gluten-Free
Soy-Free
Made in USA
6 Clinically Studied Strains
Non-Sedating
Caffeine-Free
Science-Backed Results
The Numbers Speak for Themselves
Clinical data supporting Nudora Purple
50 Billion
CFUs
Probiotic strength targeting the gut-brain connection
6
Clinically Studied Strains
Probiotics proven to support stress reduction and mood balance
7
Herbal Adaptogens
Natural stress-relief ingredients including Ashwagandha and Saffron
1-2
Weeks to Notice Benefits
Many notice appetite and energy support; fuller benefits build over 4-8 weeks
Premium Formulation
Explore Our Ingredients
Every ingredient is carefully selected, clinically studied, and precisely dosed
Clinically Studied
Bifidobacterium Infantis
Probiotics
3 Billion CFU
Potency
Key Benefits
- Reduces depression and anxiety symptoms by normalizing tryptophan metabolism
- Supports healthy serotonin production through kynurenine pathway modulation
- Reduces visceral hypersensitivity associated with stress-related gut disorders
- Restores gut barrier function to lower neuroinflammatory signaling
Clinically Studied
Bifidobacterium Longum
Probiotics
5 Billion CFU
Potency
Key Benefits
- Reduces psychological stress and anxiety through vagal nerve modulation
- Improves sleep quality and reduces sleep onset latency
- Modulates the HPA axis to normalize cortisol rhythmicity
- Produces short-chain fatty acids that support neuroprotective pathways
Clinically Studied
Lactobacillus Fermentum
Probiotics
3 Billion CFU
Potency
Key Benefits
- Supports stress resilience through immune-inflammatory modulation
- Enhances antioxidant defenses that protect against stress-induced oxidative damage
- Contributes to gut barrier integrity reducing inflammation-driven mood disruption
- Supports overall microbiome diversity for indirect mood and sleep benefits
Clinically Studied
Lactobacillus Helveticus
Probiotics
3 Billion CFU
Potency
Key Benefits
- Reduces anxiety and psychological stress responses
- Improves sleep duration and quality in clinical populations
- Produces bioactive peptides with calming neuroactive properties
- Lowers cortisol and supports healthy stress hormone regulation
Clinically Studied
Lactobacillus Plantarum
Probiotics
5 Billion CFU
Potency
Key Benefits
- Reduces anxiety and depressive symptoms through gut-brain communication
- Improves sleep efficiency by modulating neurotransmitter production
- Enhances serotonin biosynthesis from tryptophan in the gut
- Reduces neuroinflammation associated with chronic stress
Clinically Studied
Lactobacillus Rhamnosus
Probiotics
5 Billion CFU
Potency
Key Benefits
- Reduces anxiety and cortisol levels via the gut-brain axis
- Improves sleep quality by modulating GABA receptor expression
- Supports mood regulation through serotonin pathway influence
- Strengthens intestinal barrier to reduce systemic inflammation linked to stress
Organic
Organic Galactooligosaccharide (GOS)
Prebiotics
5g
Potency
Key Benefits
- Selectively feeds Bifidobacteria to enhance gut-brain axis signaling
- Reduces cortisol awakening response and perceived stress levels
- Improves sleep architecture by supporting SCFA-producing bacteria
- Enhances magnesium and calcium absorption for neuromuscular relaxation
Organic
Organic Inulin
Prebiotics
3g
Potency
Key Benefits
- Promotes growth of beneficial gut bacteria that support mood regulation
- Enhances short-chain fatty acid production for gut-brain axis communication
- Improves mineral absorption including magnesium for neuromuscular calm
- Supports healthy inflammatory response linked to stress resilience
Organic
Organic Xylooligosaccharides (XOS)
Prebiotics
1.4g
Potency
Key Benefits
- Selectively promotes Bifidobacteria growth at very low effective doses
- Reduces gut inflammation that contributes to systemic stress signaling
- Improves digestive comfort which indirectly supports sleep quality
- Enhances gut barrier function to reduce neuroinflammatory cascades
Clinically Studied
Ashwagandha
Herbals
300mg
Potency
Key Benefits
- Significantly reduces cortisol and perceived stress levels
- Improves sleep onset latency and overall sleep quality
- Enhances stress resilience by modulating the HPA axis
- Reduces anxiety symptoms with efficacy comparable to pharmaceutical anxiolytics
Clinically Studied
Lemon Balm (Melissa officinalis)
Herbals
300mg
Potency
Key Benefits
- Reduces anxiety and promotes calm without impairing alertness
- Improves mood and reduces negative emotional responses to stress
- Enhances sleep quality particularly when combined with valerian
- Supports cognitive function under stress through GABA modulation
Clinically Studied
L-Theanine
Herbals
200mg
Potency
Key Benefits
- Promotes alpha brain wave activity for calm, focused relaxation
- Reduces stress-induced blood pressure and heart rate elevations
- Improves sleep quality without causing drowsiness or next-day grogginess
- Enhances GABA, serotonin, and dopamine neurotransmitter activity
Clinically Studied
Magnesium Glycinate
Herbals
200mg
Potency
Key Benefits
- Promotes muscle relaxation and reduces physical tension from stress
- Enhances GABA receptor activity to support calm and restful sleep
- Regulates the HPA axis and normalizes cortisol secretion patterns
- Supports melatonin production and circadian rhythm regulation
Clinically Studied
Rhodiola Rosea
Herbals
200mg
Potency
Key Benefits
- Reduces mental fatigue and burnout under chronic stress conditions
- Enhances cognitive performance and focus during stressful periods
- Modulates stress hormones including cortisol and norepinephrine
- Improves mood and reduces symptoms of mild-to-moderate depression
Clinically Studied
Saffron
Herbals
30mg
Potency
Key Benefits
- Reduces depression symptoms with efficacy comparable to SSRIs
- Decreases anxiety and emotional reactivity to stress
- Improves sleep quality by enhancing serotonin and melatonin pathways
- Provides neuroprotective antioxidant activity against stress-induced damage
Clinically Studied
Valerian Root
Herbals
300mg
Potency
Key Benefits
- Reduces sleep onset latency and improves overall sleep quality
- Acts as a natural sedative through GABAergic potentiation
- Reduces anxiety and nervous restlessness without dependency risk
- Improves subjective sleep quality in mild-to-moderate insomnia
Bifidobacterium Infantis
{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"Bifidobacterium infantis is a key early-life gut commensal with significant psychobiotic potential, particularly strain 35624. Research has established its capacity to normalize the tryptophan-kynurenine metabolic axis, which is disrupted in depression and chronic stress. Its strong anti-inflammatory profile and mucosal barrier support make it relevant for the gut-brain-mood connection."}]}]}
Clinical Evidence
{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"A pivotal study by Desbonnet et al. (2008) demonstrated that B. infantis 35624 normalized tryptophan metabolism and reduced depressive-like behavior in preclinical models, effects comparable to the SSRI citalopram. Clinical trials in IBS patients showed significant improvements in comorbid anxiety and depression scores with 8-week supplementation. A 2022 systematic review in Gut Microbes confirmed consistent mood-modulating effects across human and animal studies."}]}]}
Mechanism of Action
{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"B. infantis redirects tryptophan metabolism away from the neurotoxic kynurenine pathway toward serotonin synthesis, effectively increasing central serotonin availability. It induces regulatory T-cells and anti-inflammatory IL-10 production while suppressing pro-inflammatory Th17 responses that drive neuroinflammation. The strain also produces conjugated linoleic acid and other anti-inflammatory metabolites that protect the intestinal barrier and reduce systemic endotoxin exposure affecting brain function."}]}]}
Bifidobacterium Longum
{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"Bifidobacterium longum is one of the most clinically validated psychobiotic strains, with strain 1714 showing particular promise for stress and cognitive applications. It is a dominant gut commensal whose depletion has been consistently linked to stress-related disorders and poor sleep quality. Its ability to produce neuroactive metabolites and communicate directly with the central nervous system makes it a cornerstone probiotic for mental wellness."}]}]}
Clinical Evidence
{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"A landmark randomized controlled trial by Allen et al. (2016) demonstrated that B. longum 1714 significantly reduced perceived stress and cortisol awakening response in healthy volunteers over 4 weeks. Research published in EBioMedicine showed improved sleep quality and reduced awakenings in subjects supplemented with this strain. A 2023 meta-analysis confirmed B. longum as one of the top-performing probiotic strains for anxiety and stress reduction across 15 RCTs."}]}]}
Mechanism of Action
{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"B. longum produces acetate and other short-chain fatty acids that cross the blood-brain barrier and influence microglial activation and neuroinflammation. It signals to the brain primarily via vagal afferent pathways, modulating GABA and serotonin receptor density in the amygdala and prefrontal cortex. The strain also competitively excludes pathogenic bacteria and restores microbial diversity, reducing endotoxin-driven neuroinflammation that impairs sleep architecture."}]}]}
Lactobacillus Fermentum
{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"Lactobacillus fermentum is a lactic acid-producing probiotic with emerging evidence for mental health applications, particularly through its strong antioxidant and immunomodulatory properties. While less studied as a psychobiotic than some Lactobacillus species, its role in reducing oxidative stress and supporting gut barrier function contributes to overall stress resilience. Strain ME-3 has been the focus of most clinical research."}]}]}
Clinical Evidence
{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"Clinical studies on L. fermentum ME-3 have demonstrated significant reductions in oxidative stress markers and lipid peroxidation in human subjects over 3-week supplementation periods. A 2020 study in the Journal of Functional Foods showed improvements in inflammatory cytokine profiles and quality of life measures in stressed adults. Evidence for direct mood and sleep effects is more preliminary compared to other psychobiotic strains."}]}]}
Mechanism of Action
{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"L. fermentum exerts its primary benefits through potent antioxidant activity, producing glutathione and reducing reactive oxygen species that damage neural tissue under chronic stress. It strengthens intestinal epithelial tight junctions, reducing translocation of lipopolysaccharide (LPS) and subsequent neuroinflammatory cascades. The strain also modulates T-helper cell balance toward an anti-inflammatory profile, lowering systemic cytokines that disrupt sleep-wake cycling."}]}]}
Lactobacillus Helveticus
{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"Lactobacillus helveticus is distinguished among psychobiotic strains for its potent proteolytic activity, producing bioactive casein-derived peptides with documented anxiolytic properties. Strain R0052 in particular has been extensively studied in combination formulations for stress reduction. Its ability to influence the HPA axis makes it a key probiotic for sleep and mood support."}]}]}
Clinical Evidence
{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"A well-known clinical trial by Messaoudi et al. (2005) demonstrated that L. helveticus R0052 supplementation for 30 days significantly reduced anxiety-like behavior and improved sleep quality in human subjects. A meta-analysis by Huang et al. (2022) in Frontiers in Nutrition confirmed significant reductions in perceived stress and improved mood scores across multiple RCTs involving this strain."}]}]}
Mechanism of Action
{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"L. helveticus produces angiotensin-converting enzyme (ACE) inhibitory peptides during milk fermentation that exert direct calming effects on the nervous system. It modulates the hypothalamic-pituitary-adrenal (HPA) axis, reducing corticosterone and cortisol output in response to stress. The strain also enhances GABAergic signaling and reduces pro-inflammatory cytokines such as IL-6 and TNF-alpha that interfere with sleep architecture."}]}]}
Lactobacillus Plantarum
{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"Lactobacillus plantarum is a versatile lactic acid bacterium with well-documented psychobiotic properties, particularly strains 299v and PS128. Research has shown it can influence serotonergic and dopaminergic pathways through the gut-brain axis. Its robust antioxidant and anti-inflammatory profile further supports neural health and stress resilience."}]}]}
Clinical Evidence
{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"A randomized controlled trial using L. plantarum 299v demonstrated significant improvements in cognitive stress parameters and reduced iron deficiency-related fatigue over 12 weeks. Research on strain PS128 published in Nutrients (2019) showed measurable reductions in anxiety and improved sleep onset latency in clinical populations. Multiple trials confirm its capacity to lower systemic inflammatory markers correlated with mood disturbances."}]}]}
Mechanism of Action
{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"L. plantarum modulates serotonin metabolism by influencing tryptophan availability along the kynurenine pathway, shifting metabolism away from neurotoxic quinolinic acid toward neuroprotective kynurenic acid. It produces neurotransmitters including GABA and acetylcholine locally in the gut that signal to the brain via the vagus nerve. The strain also produces antioxidant compounds that reduce oxidative stress in neural tissue and supports blood-brain barrier integrity."}]}]}
Lactobacillus Rhamnosus
{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"Lactobacillus rhamnosus is one of the most extensively studied probiotic strains for mental health applications, with particular attention to strain GG. Research has demonstrated its ability to modulate the gut-brain axis through neurotransmitter production and vagal nerve signaling. Multiple preclinical and clinical studies support its role in reducing stress and anxiety-related behaviors."}]}]}
Clinical Evidence
{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"A landmark randomized controlled trial by Messaoudi et al. (2012) showed that L. rhamnosus supplementation for 30 days significantly reduced anxiety scores and lowered urinary cortisol levels in healthy volunteers. A 2021 systematic review in Nutrients confirmed consistent anxiolytic effects across clinical populations, with notable improvements in perceived stress measures."}]}]}
Mechanism of Action
{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"L. rhamnosus modulates the gut-brain axis primarily through vagal nerve afferent signaling, influencing GABA receptor expression in the brain. It produces gamma-aminobutyric acid and short-chain fatty acids that cross the intestinal barrier and exert neuroactive effects. The strain also reduces systemic inflammation by strengthening tight junctions in the gut epithelium, thereby lowering pro-inflammatory cytokines that disrupt sleep and mood."}]}]}
Organic Galactooligosaccharide (GOS)
{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"Galactooligosaccharides (GOS) are among the most well-researched prebiotics for mental health, with clinical evidence demonstrating direct effects on stress hormones and mood. GOS selectively promotes the growth of Bifidobacterium species, which are key psychobiotic organisms. Its high fermentability and selective stimulation of beneficial gut bacteria make it a cornerstone prebiotic for the gut-brain axis."}]}]}
Clinical Evidence
{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"A landmark randomized controlled trial by Schmidt et al. (2015) published in Gut demonstrated that GOS supplementation (5.5g/day) for 3 weeks significantly reduced salivary cortisol awakening response and improved anxiety scores in healthy volunteers. A follow-up trial in 2021 confirmed these findings and additionally showed improved sleep quality measured by Pittsburgh Sleep Quality Index. GOS remains the prebiotic with the strongest direct clinical evidence for stress and mood modulation."}]}]}
Mechanism of Action
{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"GOS is selectively fermented by Bifidobacteria to produce acetate and lactate, which are further converted to butyrate by cross-feeding bacteria, supporting gut barrier integrity and reducing systemic inflammation. GOS fermentation increases circulating short-chain fatty acids that cross the blood-brain barrier and modulate microglial activity and neurotransmitter synthesis. It also enhances mineral absorption, particularly magnesium, which is a cofactor in over 300 enzymatic reactions related to nervous system function."}]}]}
Organic Inulin
{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"Inulin is a well-established fructan-type prebiotic found naturally in chicory root, Jerusalem artichoke, and other plants. It serves as a broad-spectrum fermentable substrate for multiple beneficial gut bacteria including Bifidobacteria and Lactobacilli. While its direct mental health evidence is less specific than GOS, its role in supporting overall microbiome health underpins gut-brain axis function."}]}]}
Clinical Evidence
{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"Multiple clinical trials have confirmed that inulin supplementation at 3-10g/day significantly increases Bifidobacterium populations and improves gut microbiome diversity over 4-8 weeks. A 2021 study in Scientific Reports showed that inulin-type fructans improved sleep quality in a murine model through gut microbiota-dependent mechanisms. Human clinical data for direct mood and sleep effects is emerging, with a 2023 RCT showing reduced perceived stress scores with 8-week supplementation."}]}]}
Mechanism of Action
{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"Inulin is fermented by colonic bacteria to produce short-chain fatty acids, primarily acetate and butyrate, which serve as energy sources for colonocytes and systemic signaling molecules. These SCFAs activate free fatty acid receptors (FFAR2/3) on enteroendocrine cells, stimulating release of satiety hormones and modulating vagal nerve signaling to the brain. Inulin also enhances intestinal barrier function and reduces circulating lipopolysaccharide levels, lowering systemic inflammation that can disrupt mood and sleep."}]}]}
Organic Xylooligosaccharides (XOS)
{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"Xylooligosaccharides (XOS) are emerging prebiotics derived from xylan-rich plant materials, notable for their high selectivity toward Bifidobacteria at remarkably low doses compared to other prebiotics. While less studied for direct mental health effects than GOS, XOS demonstrates strong gut microbiome modulation that indirectly supports the gut-brain axis. Its low effective dose makes it practical for combination supplement formulations."}]}]}
Clinical Evidence
{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"Clinical trials have demonstrated that XOS at doses as low as 1.4g/day significantly increases Bifidobacterium populations within 2-4 weeks of supplementation. A 2020 study in the Journal of Nutritional Science showed improvements in gut barrier markers and reduced inflammatory cytokines in healthy adults. Direct clinical evidence for mood and sleep effects is still developing, though the strong bifidogenic effect supports indirect benefits through established gut-brain pathways."}]}]}
Mechanism of Action
{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"XOS is selectively fermented by Bifidobacteria through xylose metabolic pathways, producing short-chain fatty acids that lower colonic pH and inhibit pathogenic bacterial growth. This selective fermentation enhances the relative abundance of psychobiotic Bifidobacteria species, amplifying their neurotransmitter-modulating and anti-inflammatory effects. XOS also increases production of butyrate through cross-feeding mechanisms, which strengthens tight junctions in the intestinal epithelium and reduces translocation of inflammatory bacterial products."}]}]}
Ashwagandha
{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"Ashwagandha (Withania somnifera) is an adaptogenic herb with the strongest clinical evidence base among natural stress-relief compounds. Root extracts standardized to withanolide content, particularly KSM-66 and Sensoril, have been extensively studied in randomized controlled trials. Its classification as a rasayana (rejuvenator) in Ayurvedic medicine aligns with modern evidence demonstrating comprehensive stress-modulating and sleep-enhancing effects."}]}]}
Clinical Evidence
{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"A landmark RCT by Pratte et al. (2014) showed that KSM-66 ashwagandha at 300mg twice daily significantly reduced perceived stress and cortisol levels by up to 30% compared to placebo over 60 days. A 2021 systematic review and meta-analysis in the Journal of Functional Foods analyzing 12 RCTs confirmed significant improvements in sleep quality (PSQI scores), anxiety (HAM-A scores), and stress markers. The sleep-specific trial by Langade et al. (2019) demonstrated ashwagandha significantly improved sleep efficiency and onset latency in insomniac patients."}]}]}
Mechanism of Action
{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"Ashwagandha modulates the hypothalamic-pituitary-adrenal (HPA) axis by normalizing cortisol secretion patterns and reducing chronic hyperactivation of the stress response. Its active withanolides function as GABA mimetics, binding to GABA-A receptors and producing anxiolytic and sedative effects similar to benzodiazepines but without dependency risk. Withania somnifera also exhibits anti-inflammatory properties by inhibiting NF-kappaB signaling and reducing pro-inflammatory cytokines that disrupt sleep architecture and mood homeostasis."}]}]}
Lemon Balm (Melissa officinalis)
{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"Lemon balm (Melissa officinalis) is a member of the mint family with documented use as a calming agent dating back to medieval times. Its essential oil contains rosmarinic acid and citral, which have demonstrated anxiolytic and mild sedative properties in both preclinical and clinical studies. It is particularly valued for its ability to reduce anxiety and stress without causing significant sedation or cognitive impairment."}]}]}
Clinical Evidence
{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"A double-blind RCT by Kennedy et al. (2004) demonstrated that lemon balm extract at 600mg significantly reduced anxiety and improved calmness in healthy volunteers under acute stress. A 2014 clinical trial published in the Mediterranean Journal of Nutrition and Metabolism showed improved sleep quality and reduced insomnia symptoms with 15 days of lemon balm supplementation. Combination studies with valerian root have consistently shown synergistic effects on sleep quality that exceed either herb alone."}]}]}
Mechanism of Action
{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"Lemon balm's primary mechanism involves inhibition of GABA transaminase, the enzyme responsible for breaking down GABA, thereby increasing GABA levels in synaptic clefts and enhancing inhibitory neurotransmission. Rosmarinic acid, a major constituent, inhibits gamma-aminobutyric acid transaminase and also acts as an anxiolytic through GABA-A receptor modulation. Lemon balm additionally inhibits acetylcholinesterase at higher concentrations, which may contribute to its cognitive-enhancing effects under stress by maintaining acetylcholine availability in brain regions involved in attention and mood regulation."}]}]}
L-Theanine
{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"L-Theanine is a unique amino acid found primarily in green tea (Camellia sinensis) that crosses the blood-brain barrier within 30-40 minutes of ingestion. It is distinguished by its ability to promote relaxation without sedation, making it ideal for daytime stress management and evening wind-down. Its well-characterized effects on brain wave patterns and neurotransmitter systems are supported by robust neuroimaging and clinical data."}]}]}
Clinical Evidence
{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"A randomized controlled trial by Kimura et al. (2007) demonstrated that 200mg L-theanine significantly increased alpha wave activity and reduced heart rate responses to acute stress. A 2019 systematic review in Plant Foods for Human Nutrition confirmed consistent reductions in stress and anxiety scores across 9 RCTs. A double-blind study by Rao et al. (2015) showed that L-theanine at 200mg/day for 4 weeks significantly improved sleep quality in boys with ADHD, with benefits extending to sleep efficiency and reduced nocturnal awakenings."}]}]}
Mechanism of Action
{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"L-Theanine crosses the blood-brain barrier and acts as a glutamate analogue, binding to glutamate receptors and modulating excitatory neurotransmission without blocking it entirely. It increases GABA concentration in the brain, enhancing inhibitory signaling that counters excitatory stress responses. L-Theanine also boosts alpha brain wave production (8-13 Hz), which is associated with a wakeful relaxation state, and increases brain-derived neurotrophic factor (BDNF) levels that support neuroplasticity and stress resilience."}]}]}
Magnesium Glycinate
{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"Magnesium glycinate combines elemental magnesium with the amino acid glycine, providing dual calming mechanisms in a highly bioavailable chelated form. Magnesium deficiency is prevalent and has been consistently linked to poor sleep, heightened stress reactivity, and mood disturbances. The glycinate form offers superior absorption and gastrointestinal tolerability compared to oxide or citrate forms."}]}]}
Clinical Evidence
{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"A double-blind RCT by Abbasi et al. (2012) demonstrated that magnesium supplementation (500mg/day) significantly improved sleep quality, sleep duration, and serum melatonin concentration in elderly insomniacs. A 2017 meta-analysis in Nutrients confirmed significant reductions in perceived stress and anxiety scores with magnesium supplementation across 18 RCTs. Research specifically using magnesium glycinate shows enhanced efficacy due to the synergistic calming effects of glycine, which itself has been shown to improve sleep quality at doses of 3g."}]}]}
Mechanism of Action
{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"Magnesium acts as a natural calcium channel blocker, preventing excessive neuronal excitation and promoting relaxation of both smooth and skeletal muscle. It functions as a positive allosteric modulator of GABA-A receptors, enhancing the inhibitory neurotransmission required for sleep onset and maintenance. Glycine, the amino acid chelate partner, independently acts as an inhibitory neurotransmitter in the spinal cord and brainstem, lowering core body temperature and facilitating sleep onset through NMDA receptor antagonism."}]}]}
Rhodiola Rosea
{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"Rhodiola rosea is an adaptogenic herb with extensive clinical evidence for stress and fatigue management, standardized to active compounds rosavin and salidroside. Its use in Scandinavian and Russian traditional medicine for endurance and stress resilience is now supported by modern pharmacological research. It is particularly valued for combating stress-related fatigue without the sedative effects common to other calming botanicals."}]}]}
Clinical Evidence
{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"A randomized controlled trial by Darbinyan et al. (2000) demonstrated that Rhodiola extract at 200mg twice daily significantly reduced fatigue and improved mental performance in physicians working night shifts. A 2015 meta-analysis in Phytomedicine confirmed significant improvements in stress, fatigue, and mood symptoms across 11 RCTs with effects typically observed within 1-2 weeks. A 2022 trial published in Frontiers in Pharmacology showed significant reductions in burnout symptoms and cortisol levels after 12 weeks of supplementation."}]}]}
Mechanism of Action
{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"Rhodiola modulates the sympathoadrenal system by regulating norepinephrine, dopamine, and serotonin levels through inhibition of monoamine oxidase A and B enzymes. Its active compound salidroside activates AMP-activated protein kinase (AMPK), enhancing cellular energy production and stress resistance at the mitochondrial level. Rhodiola also modulates cortisol secretion by influencing the HPA axis, preventing both hyperactivation during acute stress and exhaustion during chronic stress, thereby maintaining adaptive stress hormone responses."}]}]}
Saffron
{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"Saffron (Crocus sativus) extract, standardized to crocin and safranal, has emerged as one of the most potent natural antidepressants supported by clinical evidence. Multiple head-to-head trials have demonstrated non-inferiority to SSRIs including fluoxetine and citalopram for mild-to-moderate depression. Its rapid onset of action, typically within 1-2 weeks, distinguishes it from many other natural mood-supporting compounds."}]}]}
Clinical Evidence
{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"A comprehensive meta-analysis by Hausenblas et al. (2013) in the Journal of Integrative Medicine confirmed that saffron extract at 30mg/day significantly reduced depression scores with effect sizes comparable to standard antidepressant medications. A 2018 RCT published in Pharmacopsychiatry demonstrated significant improvements in both anxiety and sleep quality after 6 weeks of supplementation. Multiple double-blind RCTs have shown non-inferiority to fluoxetine (Prozac) for mild-to-moderate depression with a superior side effect profile."}]}]}
Mechanism of Action
{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"Saffron's active compounds crocin and safranal inhibit serotonin reuptake at synaptic clefts, increasing serotonergic signaling similarly to SSRIs but through a non-competitive mechanism. Safranal additionally modulates GABA-A receptor activity, producing anxiolytic and mildly sedative effects that support relaxation and sleep onset. Crocin provides potent antioxidant activity by scavenging free radicals and upregulating Nrf2-dependent antioxidant enzymes, protecting neurons from oxidative stress caused by chronic psychological stress."}]}]}
Valerian Root
{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"Valerian (Valeriana officinalis) root extract is one of the most traditionally used botanical sleep aids in Western herbal medicine, with a history spanning over 2,000 years. Its standardized extracts contain valerenic acids, which are the primary bioactive compounds responsible for sedative and anxiolytic effects. While clinical evidence shows moderate efficacy, it remains one of the most widely used and safest natural sleep aids available."}]}]}
Clinical Evidence
{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"A systematic review and meta-analysis by Fernandez-San-Martin et al. (2010) concluded that valerian extract at 300-600mg improves subjective sleep quality with a statistically significant effect size compared to placebo. A 2011 RCT published in the European Journal of Medical Research demonstrated significant improvements in sleep quality and reduced sleep latency over 28 days of supplementation. Results are generally more pronounced with regular use over 2-4 weeks compared to single-dose acute use."}]}]}
Mechanism of Action
{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"Valerenic acid, the primary active compound, acts as a positive allosteric modulator of GABA-A receptors, enhancing inhibitory neurotransmission and promoting sedation through the same receptor class targeted by benzodiazepines. Valerian also inhibits the enzymatic breakdown of GABA by blocking GABA transaminase, increasing synaptic GABA availability in the brain. Additionally, valerian extracts contain adenosine receptor agonists that contribute to sleep-promoting effects by activating the same receptor targeted by caffeine's antagonistic action."}]}]}
Your Transformation Journey
What to Expect & When
Track your progress with Nudora Purple — real results, real timeline
First Signs
- Reduces Stress & Anxiety
- Boosts Mood & Mental Clarity
Building Momentum
- Lowers Cortisol for Calmness
- Supports Better Sleep
Noticeable Changes
- Gut Health Support
- Balances Hormones
Peak Results
- Supports Serotonin & Neurotransmitters
- Reduces Pain & Inflammation
- Improve Sleep
- Decrease Bloating & Digestive Issues
How to Take
Your Usage Guide
Simple instructions for the best results with Nudora Purple
Serving Size
2 capsules
Frequency
Once daily
Best Time
Evening, after dinner
With Food
Take with food
Got Questions?
Frequently Asked Questions
Everything you need to know about Nudora Purple
{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"Purple combines Ashwagandha, Saffron, L-Theanine, Valerian, and probiotics "},{"type":"text","value":"to","bold":true},{"type":"text","value":" support calm, mood balance, and relaxation, "},{"type":"text","value":"while","bold":true},{"type":"text","value":" helping maintain mental clarity."}]}]}
{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"No—this "},{"type":"text","value":"isn't","bold":true},{"type":"text","value":" a replacement "},{"type":"text","value":"for","bold":true},{"type":"text","value":" medications "},{"type":"text","value":"or","bold":true},{"type":"text","value":" prescribed supplements. Purple provides daily relaxation "},{"type":"text","value":"and","bold":true},{"type":"text","value":" mood support; talk "},{"type":"text","value":"to","bold":true},{"type":"text","value":" your healthcare provider "},{"type":"text","value":"before","bold":true},{"type":"text","value":" changing your regimen."}]}]}
{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"It's non-sedating "},{"type":"text","value":"for","bold":true},{"type":"text","value":" most people. It supports relaxation "},{"type":"text","value":"without","bold":true},{"type":"text","value":" heavy drowsiness. If you feel sleepy, take "},{"type":"text","value":"itinthe","bold":true},{"type":"text","value":" evening."}]}]}
{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"Either works. Many people prefer evening "},{"type":"text","value":"for","bold":true},{"type":"text","value":" its relaxation support. "},{"type":"text","value":"If","bold":true},{"type":"text","value":" you"},{"type":"text","value":"'re sensitive to calming herbs, start at night and adjust as you like.","italic":true}]}]}
{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"Some feel "},{"type":"text","value":"a","bold":true},{"type":"text","value":" sense "},{"type":"text","value":"of","bold":true},{"type":"text","value":" calm "},{"type":"text","value":"within","bold":true},{"type":"text","value":"1–2 weeks; fuller benefits may build over 4–6 weeks "},{"type":"text","value":"of","bold":true},{"type":"text","value":" consistent daily use."}]}]}
{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"Yes. Purple pairs well "},{"type":"text","value":"with","bold":true},{"type":"text","value":" Green "},{"type":"text","value":"for","bold":true},{"type":"text","value":" gut support, "},{"type":"text","value":"and","bold":true},{"type":"text","value":" many also use Orange 2.0"},{"type":"text","value":"for","bold":true},{"type":"text","value":" metabolic support. Follow "},{"type":"text","value":"each","bold":true},{"type":"text","value":" label"},{"type":"text","value":"'s directions.","italic":true}]}]}
{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"Purple fits most routines "},{"type":"text","value":"and","bold":true},{"type":"text","value":" contains no caffeine. "},{"type":"text","value":"If","bold":true},{"type":"text","value":" you "},{"type":"text","value":"use","bold":true},{"type":"text","value":" other supplements "},{"type":"text","value":"or","bold":true},{"type":"text","value":" prescriptions, consult your healthcare professional."}]}]}
{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"No. It's non-addictive "},{"type":"text","value":"and","bold":true},{"type":"text","value":" designed "},{"type":"text","value":"for","bold":true},{"type":"text","value":" gentle, daily support."}]}]}
{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"If","bold":true},{"type":"text","value":" you're pregnant, nursing, under 18, "},{"type":"text","value":"or","bold":true},{"type":"text","value":" have a medical condition ("},{"type":"text","value":"or","bold":true},{"type":"text","value":" take prescription meds), consult your healthcare provider before "},{"type":"text","value":"use","bold":true},{"type":"text","value":"."}]}]}
{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"Yes—open"},{"type":"text","value":"and","bold":true},{"type":"text","value":" mix "},{"type":"text","value":"intoa","bold":true},{"type":"text","value":" cool smoothie "},{"type":"text","value":"or","bold":true},{"type":"text","value":" yogurt. Avoid hot liquids that may affect delicate ingredients."}]}]}
{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"Yes","bold":true},{"type":"text","value":". 100% plant-based, Non-GMO, dairy-"},{"type":"text","value":"free","bold":true},{"type":"text","value":", gluten-"},{"type":"text","value":"free","bold":true},{"type":"text","value":", soy-"},{"type":"text","value":"free","bold":true},{"type":"text","value":", "},{"type":"text","value":"no","bold":true},{"type":"text","value":" additives, "},{"type":"text","value":"no","bold":true},{"type":"text","value":" sweeteners."}]}]}
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